Ontology highlight
ABSTRACT:
SUBMITTER: Darlington A
PROVIDER: S-EPMC7039862 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Darlington Ashley A McCauley Mark D MD
Frontiers in cardiovascular medicine 20200218
The most dreaded complication of atrial fibrillation is stroke, and 70-80% of patients with AF-related stroke die or become disabled. The mechanisms of thromboembolism in AF are multifactorial, with evidence demonstrating that all three criteria of Virchow's triad are satisfied in AF: abnormal stasis of blood, endothelial damage, and hypercoagulability. Mechanistic insights into the latter two limbs have resulted in effective stroke prophylactic therapies (left atrial appendage occlusion and ora ...[more]