Ontology highlight
ABSTRACT:
SUBMITTER: Gulfidan G
PROVIDER: S-EPMC7039988 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Gulfidan Gizem G Turanli Beste B Beklen Hande H Sinha Raghu R Arga Kazim Yalcin KY
Scientific reports 20200224 1
Deciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome Atlas for 12 different cancers. Utilizing the gene expression levels as a proxy, we have identified the differential protein-protein interactions in each cancer type and presented a differential view of human protein interactome among the cancers. We clearl ...[more]