Dataset Information

Retaining information from multidimensional correlation MRI using a spectral regions of interest generator.

ABSTRACT: Multidimensional correlation magnetic resonance imaging (MRI) is an emerging imaging modality that is capable of disentangling highly heterogeneous and opaque systems according to chemical and physical interactions of water within them. Using this approach, the conventional three dimensional MR scalar images are replaced with spatially resolved multidimensional spectra. The ensuing abundance in microstructural and chemical information is a blessing that incorporates a real challenge: how does one distill and refine it into images while retaining its significant components? In this paper we introduce a general framework that preserves the spectral information from spatially resolved multidimensional data. Equal weight is given to significant spectral components at the single voxel level, resulting in a summarized image spectrum. This spectrum is then used to define spectral regions of interest that are utilized to reconstruct images of sub-voxel components. Using numerical simulations we first show that, contrary to the conventional approach, the proposed framework preserves spectral resolution, and in turn, sensitivity and specificity of the reconstructed images. The retained spectral resolution allows, for the first time, to observe an array of distinct [Formula: see text]-[Formula: see text]-[Formula: see text] components images of the human brain. The robustly generated images of sub-voxel components overcome the limited spatial resolution of MRI, thus advancing multidimensional correlation MRI to fulfilling its full potential.

SUBMITTER: Pas K

PROVIDER: S-EPMC7040019 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Retaining information from multidimensional correlation MRI using a spectral regions of interest generator.

Pas Kristofor K Komlosh Michal E ME Perl Daniel P DP Basser Peter J PJ Benjamini Dan D

Scientific reports 20200224 1

Multidimensional correlation magnetic resonance imaging (MRI) is an emerging imaging modality that is capable of disentangling highly heterogeneous and opaque systems according to chemical and physical interactions of water within them. Using this approach, the conventional three dimensional MR scalar images are replaced with spatially resolved multidimensional spectra. The ensuing abundance in microstructural and chemical information is a blessing that incorporates a real challenge: how does on ...[more]

PMID: 32094400

Similar Datasets

Project description:BackgroundGenomic information allows population relatedness to be inferred and selected genes to be identified. Single nucleotide polymorphism microarray (SNP-chip) data, a proxy for genome composition, contains patterns in allele order and proportion. These patterns can be quantified by compression efficiency (CE). In principle, the composition of an entire genome can be represented by a CE number quantifying allele representation and order.ResultsWe applied a compression algorithm (DEFLATE) to genome-wide high-density SNP data from 4,155 human, 1,800 cattle, 1,222 sheep, 81 dogs and 49 mice samples. All human ethnic groups can be clustered by CE and the clusters recover phylogeography based on traditional fixation index (FST) analyses. CE analysis of other mammals results in segregation by breed or species, and is sensitive to admixture and past effective population size. This clustering is a consequence of individual patterns such as runs of homozygosity. Intriguingly, a related approach can also be used to identify genomic loci that show population-specific CE segregation. A high resolution CE 'sliding window' scan across the human genome, organised at the population level, revealed genes known to be under evolutionary pressure. These include SLC24A5 (European and Gujarati Indian skin pigmentation), HERC2 (European eye color), LCT (European and Maasai milk digestion) and EDAR (Asian hair thickness). We also identified a set of previously unidentified loci with high population-specific CE scores including the chromatin remodeler SCMH1 in Africans and EDA2R in Asians. Closer inspection reveals that these prioritised genomic regions do not correspond to simple runs of homozygosity but rather compositionally complex regions that are shared by many individuals of a given population. Unlike FST, CE analyses do not require ab initio population comparisons and are amenable to the hemizygous X chromosome.ConclusionsWe conclude with a discussion of the implications of CE for a complex systems science view of genome evolution. CE allows one to clearly visualise the evolution of individual genomes and populations through a formal, mathematically-rigorous information space. Overall, CE makes a set of biological predictions, some of which are unique and await functional validation.

Dataset Information

Retaining information from multidimensional correlation MRI using a spectral regions of interest generator.

Publications

Retaining information from multidimensional correlation MRI using a spectral regions of interest generator.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure