Ontology highlight
ABSTRACT:
SUBMITTER: Rosas-Ballina M
PROVIDER: S-EPMC7040478 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Rosas-Ballina Mauricio M Guan Xue Li XL Schmidt Alexander A Bumann Dirk D
Frontiers in immunology 20200218
Altered lipid metabolism in macrophages is associated with various important inflammatory conditions. Although lipid metabolism is an important target for therapeutic intervention, the metabolic requirement involved in lipid accumulation during pro-inflammatory activation of macrophages remains incompletely characterized. We show here that macrophage activation with IFNγ results in increased aerobic glycolysis, iNOS-dependent inhibition of respiration, and accumulation of triacylglycerol. Surpri ...[more]