Ontology highlight
ABSTRACT:
SUBMITTER: Chen YJ
PROVIDER: S-EPMC7041682 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Chen Yu-Jie YJ Williams Jeffrey M JM Arvan Peter P Tsai Billy B
The Journal of cell biology 20200201 2
Escape of large macromolecular complexes from the endoplasmic reticulum (ER), such as a viral particle or cellular aggregate, likely induces mechanical stress initiated on the luminal side of the ER membrane, which may threaten its integrity. How the ER responds to this threat remains unknown. Here we demonstrate that the cytosolic leaflet ER morphogenic protein reticulon (RTN) protects ER membrane integrity when polyomavirus SV40 escapes the ER to reach the cytosol en route to infection. SV40 c ...[more]