Ontology highlight
ABSTRACT:
SUBMITTER: Luedtke DA
PROVIDER: S-EPMC7042303 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Luedtke Daniel A DA Su Yongwei Y Ma Jun J Li Xinyu X Buck Steven A SA Edwards Holly H Polin Lisa L Kushner Juiwanna J Dzinic Sijana H SH White Kathryn K Lin Hai H Taub Jeffrey W JW Ge Yubin Y
Signal transduction and targeted therapy 20200226 1
Venetoclax, an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia (AML), is tolerated well in elderly patients with AML and has good overall response rates; however, resistance remains a concern. In this study, we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples. CDK9 inhibition enhances venetoclax activity through ...[more]