Association of catechol-O-methyltranferase 472G>A (Val158Met) polymorphism with susceptibility to fibromyalgia syndrome.
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ABSTRACT: Background
Several lines of research have suggested that the 472G > A (Val158Met) polymorphism at Catechol-O-methyltranferase (COMT) gene is implicated in the pathophysiology of FMS. Here, we have evaluated the association of COMT 472G > A polymorphism with risk of FMS.Methods
In this study 250 patients with FMS and 250 healthy controls were evaluated for COMT 472G > A polymorphism by RFLP-PCR assay.Results
There were no significant differences in the allele and genotype frequencies of COMT 472G > A polymorphism between FMS cases and healthy controls.Conclusions
Our results suggested that the COMT 472G > A polymorphism may not be risk factor for development of FMS.
SUBMITTER: Hatami M
PROVIDER: S-EPMC7042409 | biostudies-literature |
REPOSITORIES: biostudies-literature
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