Ontology highlight
ABSTRACT:
SUBMITTER: Schommers P
PROVIDER: S-EPMC7042716 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cell 20200130 3
Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and treat HIV-1 infection. However, viral escape through mutation of the HIV-1 envelope glycoprotein (Env) limits clinical applications. Here we describe 1-18, a new V<sub>H</sub>1-46-encoded CD4 binding site (CD4bs) bNAb with outstanding breadth (97%) and potency (GeoMean IC<sub>50</sub> = 0.048 μg/mL). Notably, 1-18 is not susceptible to typical CD4bs escape mutations and effectively overcomes HIV-1 resistance to ...[more]