Ontology highlight
ABSTRACT:
SUBMITTER: Geng H
PROVIDER: S-EPMC7043225 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Geng Hongwei H Song Qinglong Q Cheng Yunyun Y Li Haoyang H Yang Rui R Liu Songcai S Hao Linlin L
International journal of molecular sciences 20200207 3
Dexamethasone (Dex) has been widely used as a potent anti-inflammatory, antishock, and immunosuppressive agent. However, high dose or long-term use of Dex is accompanied by side effects including skeletal muscle atrophy, whose underlying mechanisms remain incompletely understood. A number of microRNAs (miRNAs) have been shown to play key roles in skeletal muscle atrophy. Previous studies showed significantly increased miR-322 expression in Dex-treated C2C12 myotubes. In our study, the glucocorti ...[more]