Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers.
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ABSTRACT:
SUBMITTER: Wu JS
PROVIDER: S-EPMC7043886 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers.
Wu Jingjing Sherry JS Yi Eunyoung E Manca Marco M Javaid Hamad H Lauer Amanda M AM Glowatzki Elisabeth E
eLife 20200124
Lateral olivocochlear (LOC) efferent neurons modulate auditory nerve fiber (ANF) activity using a large repertoire of neurotransmitters, including dopamine (DA) and acetylcholine (ACh). Little is known about how individual neurotransmitter systems are differentially utilized in response to the ever-changing acoustic environment. Here we present quantitative evidence in rodents that the dopaminergic LOC input to ANFs is dynamically regulated according to the animal's recent acoustic experience. S ...[more]
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