Ontology highlight
ABSTRACT:
SUBMITTER: Filova I
PROVIDER: S-EPMC7547283 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Filova Iva I Dvorakova Martina M Bohuslavova Romana R Pavlinek Adam A Elliott Karen L KL Vochyanova Simona S Fritzsch Bernd B Pavlinkova Gabriela G
Molecular neurobiology 20200903 12
Ear development requires the transcription factors ATOH1 for hair cell differentiation and NEUROD1 for sensory neuron development. In addition, NEUROD1 negatively regulates Atoh1 gene expression. As we previously showed that deletion of the Neurod1 gene in the cochlea results in axon guidance defects and excessive peripheral innervation of the sensory epithelium, we hypothesized that some of the innervation defects may be a result of abnormalities in NEUROD1 and ATOH1 interactions. To characteri ...[more]