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Urinary metabolites and risk of coronary heart disease: A prospective investigation among urban Chinese adults.

ABSTRACT: BACKGROUND AND AIMS:Studies have linked several metabolites to the risk of coronary heart disease (CHD) among Western populations, but prospective studies among Asian populations on the metabolite-CHD association remain limited. METHODS AND RESULTS:We evaluated the association of urinary metabolites with CHD risk among Chinese adults in a nested case-control study of 275 incident cases and 275 matched controls (127 pairs of men and 148 pairs of women). Fifty metabolites were measured by a predefined metabolomics panel and adjusted using urinary creatinine. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). After adjusting for traditional CHD risk factors, urinary tryptophan showed a positive association with incident CHD: OR (95% CI) for the highest vs. lowest quartiles was 2.02 (1.15-3.56) among all study participants (p-trend = 0.02). The tryptophan-CHD association was more evident among individuals with dyslipidemia than among those without the condition (OR [95% CI] for the highest vs. lowest quartiles = 3.90 [1.86-8.19] and 0.74 [0.26-2.06], respectively; p-interaction<0.01). Other metabolites did not show significant associations with CHD risk among all study participants. However, a positive association of methionine with CHD risk was observed only among women (OR [95% CI] for the highest vs. lowest quartiles = 2.77 [1.17-6.58]; p-interaction = 0.03), and an inverse association of inosine with CHD risk was observed only among men (OR [95% CI] for the highest vs. lowest quartiles = 0.29 [0.11-0.81]; p-interaction = 0.04). CONCLUSION:Elevated urinary tryptophan may be related to CHD risk among Chinese adults, especially for those with dyslipidemia.

SUBMITTER: Yoon HS

PROVIDER: S-EPMC7044070 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Urinary metabolites and risk of coronary heart disease: A prospective investigation among urban Chinese adults.

Yoon Hyung-Suk HS Jeong Yang Jae J Rivera Emilio S ES Shu Xiao-Ou XO Xiang Yong-Bing YB Calcutt Marion W MW Cai Qiuyin Q Zhang Xianglan X Li Honglan H Gao Yu-Tang YT Zheng Wei W Yu Danxia D

Nutrition, metabolism, and cardiovascular diseases : NMCD 20191105 3

<h4>Background and aims</h4>Studies have linked several metabolites to the risk of coronary heart disease (CHD) among Western populations, but prospective studies among Asian populations on the metabolite-CHD association remain limited.<h4>Methods and results</h4>We evaluated the association of urinary metabolites with CHD risk among Chinese adults in a nested case-control study of 275 incident cases and 275 matched controls (127 pairs of men and 148 pairs of women). Fifty metabolites were measu ...[more]

PMID: 31831367

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Dataset Information

Urinary metabolites and risk of coronary heart disease: A prospective investigation among urban Chinese adults.

Publications

Urinary metabolites and risk of coronary heart disease: A prospective investigation among urban Chinese adults.

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