Urinary metabolites and risk of coronary heart disease: A prospective investigation among urban Chinese adults.

ABSTRACT:

Background and aims

Studies have linked several metabolites to the risk of coronary heart disease (CHD) among Western populations, but prospective studies among Asian populations on the metabolite-CHD association remain limited.

Methods and results

We evaluated the association of urinary metabolites with CHD risk among Chinese adults in a nested case-control study of 275 incident cases and 275 matched controls (127 pairs of men and 148 pairs of women). Fifty metabolites were measured by a predefined metabolomics panel and adjusted using urinary creatinine. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). After adjusting for traditional CHD risk factors, urinary tryptophan showed a positive association with inciden

SUBMITTER: Yoon HS 

PROVIDER: S-EPMC7044070 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature