Ontology highlight
ABSTRACT:
SUBMITTER: Cao H
PROVIDER: S-EPMC7044337 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cao Hong H Krueger E W EW Chen Jing J Drizyte-Miller Kristina K Schulz Mary E ME McNiven Mark A MA
Nature communications 20200226 1
The membrane deforming dynamin family members MxA and MxB are large GTPases that convey resistance to a variety of infectious viruses. During viral infection, Mx proteins are known to show markedly increased expression via an interferon-responsive promoter to associate with nuclear pores. In this study we report that MxB is an inner mitochondrial membrane GTPase that plays an important role in the morphology and function of this organelle. Expression of mutant MxB or siRNA knockdown of MxB leads ...[more]