Dataset Information

Amine-Functionalized ZIF-8 as a Fluorescent Probe for Breath Volatile Organic Compound Biomarker Detection of Lung Cancer Patients.

ABSTRACT: The highly thermally and chemically stable imidazole framework ZIF-8 samples were separately postmodified with amine groups by using N,N'-dimethylethylenediamine (MMEN) and N,N-dimethylaminoethylamine (MAEA), which had the same molecular formula but different structures. The modified ZIF-8 samples (ZIF-8@amine) were thoroughly characterized, including powder X-ray diffractometry, Fourier-transformed infrared spectroscopy, and physical adsorption at 77 K by nitrogen, thermogravimetric analysis, and photophysical characterization. Results showed that after modification, the Brunauer-Emmett-Teller surface area and total pore volume both increased, almost one time higher than those of the original ZIF-8 sample, and followed the order: ZIF-8-MMEN > ZIF-8-MAEA > ZIF-8. Furthermore, the N-H group was successfully grafted into the modified ZIF-8 samples. To examine the sensing properties of the modified ZIF-8@amine samples toward the breath biomarkers of lung cancer, five potential volatile organic compound biomarkers were used as analytes. ZIF-8-MMEN and ZIF-8-MAEA revealed a unique capacity for sensing hexanal, ethylbenzene, and 1-propanol with high efficiency and sensitivity. The three samples all did not show sensing ability toward styrene and isoprene. In addition, ZIF-8, ZIF-8-MMEN, and ZIF-8-MAEA all can sense hexanal with a detection limit as low as 1 ppb.

SUBMITTER: Xia Y

PROVIDER: S-EPMC7045493 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Amine-Functionalized ZIF-8 as a Fluorescent Probe for Breath Volatile Organic Compound Biomarker Detection of Lung Cancer Patients.

Xia Yuanhan Y Hong Yi Y Geng Rongchuang R Li Xue X Qu Ailan A Zhou Zhen Z Zhang Zhijuan Z

ACS omega 20200213 7

The highly thermally and chemically stable imidazole framework ZIF-8 samples were separately postmodified with amine groups by using N,N'-dimethylethylenediamine (MMEN) and N,N-dimethylaminoethylamine (MAEA), which had the same molecular formula but different structures. The modified ZIF-8 samples (ZIF-8@amine) were thoroughly characterized, including powder X-ray diffractometry, Fourier-transformed infrared spectroscopy, and physical adsorption at 77 K by nitrogen, t ...[more]

PMID: 32118162

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Project description:ImportanceThe detection and quantification of volatile organic compounds (VOCs) within exhaled breath have evolved gradually for the diagnosis of cancer. The overall diagnostic accuracy of proposed tests remains unknown.ObjectivesTo determine the diagnostic accuracy of VOC breath tests for the detection of cancer and to review sources of methodologic variability.Data sourcesAn electronic search (title and abstract) was performed using the Embase and MEDLINE databases (January 1, 2000, to May 28, 2017) through the OVID platform. The search terms cancer, neoplasm, malignancy, volatile organic compound, VOC, breath, and exhaled were used in combination with the Boolean operators AND and OR. A separate MEDLINE search that used the search terms breath AND methodology was also performed for studies that reported factors that influenced the concentration of VOCs within exhaled breath in humans.Study selectionThe search was limited to human studies published in the English language. Trials that analyzed named endogenous VOCs within exhaled breath to diagnose or assess cancer were included in this review.Data extraction and synthesisSystematic review and pooled analysis were conducted in accordance with the recommendations of the Cochrane Library and Meta-analysis of Observational Studies in Epidemiology guidelines. Bivariate meta-analyses were performed to generate pooled point estimates of the hierarchal summary receiver operating characteristic curve of breath VOC analysis. Included studies were assessed according to the Standards for Reporting of Diagnostic Accuracy Studies checklist and Quality Assessment of Diagnostic Accuracy Studies 2 tool.Main outcomes and measuresThe principal outcome measure was pooled diagnostic accuracy of published VOC breath tests for cancer.ResultsThe review identified 63 relevant publications and 3554 patients. All reports constituted phase 1 biomarker studies. Pooled analysis of findings found a mean (SE) area under the receiver operating characteristic analysis curve of 0.94 (0.01), sensitivity of 79% (95% CI, 77%-81%), and specificity of 89% (95% CI, 88%-90%). Factors that may influence variability in test results included breath collection method, patient physiologic condition, test environment, and method of analysis.Conclusions and relevanceThe findings of our review suggest that standardization of breath collection methods and masked validation of breath test accuracy for cancer diagnosis is needed among the intended population in multicenter clinical trials. We propose a framework to guide the conduct of future breath tests in cancer studies.

Dataset Information

Amine-Functionalized ZIF-8 as a Fluorescent Probe for Breath Volatile Organic Compound Biomarker Detection of Lung Cancer Patients.

Publications

Amine-Functionalized ZIF-8 as a Fluorescent Probe for Breath Volatile Organic Compound Biomarker Detection of Lung Cancer Patients.

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