Ontology highlight
ABSTRACT:
SUBMITTER: Wan L
PROVIDER: S-EPMC7045805 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Wan Li L Essuman Kow K Anderson Ryan G RG Sasaki Yo Y Monteiro Freddy F Chung Eui-Hwan EH Osborne Nishimura Erin E DiAntonio Aaron A Milbrandt Jeffrey J Dangl Jeffery L JL Nishimura Marc T MT
Science (New York, N.Y.) 20190801 6455
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors activate cell death and confer disease resistance by unknown mechanisms. We demonstrate that plant Toll/interleukin-1 receptor (TIR) domains of NLRs are enzymes capable of degrading nicotinamide adenine dinucleotide in its oxidized form (NAD<sup>+</sup>). Both cell death induction and NAD<sup>+</sup> cleavage activity of plant TIR domains require known self-association interfaces and a putative catalytic glutamic acid that is co ...[more]