Ontology highlight
ABSTRACT:
SUBMITTER: Hu DJ
PROVIDER: S-EPMC7046008 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Hu Daniel Jun-Kit DJ Jasper Heinrich H
Cell reports 20190901 11
Tissue homeostasis depends on precise yet plastic regulation of stem cell daughter fates. During growth, Drosophila intestinal stem cells (ISCs) adjust fates by switching from asymmetric to symmetric lineages to scale the size of the ISC population. Using a combination of long-term live imaging, lineage tracing, and genetic perturbations, we demonstrate that this switch is executed through the control of mitotic spindle orientation by Jun-N-terminal kinase (JNK) signaling. JNK interacts with the ...[more]