Identification of gamma heavy chain disease using MALDI-TOF mass spectrometry.
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ABSTRACT:
SUBMITTER: Thoren KL
PROVIDER: S-EPMC7046309 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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Identification of gamma heavy chain disease using MALDI-TOF mass spectrometry.
Thoren Katie L KL Eveillard Marion M Chan Patrick P Doddi Sital S Cho Sun S Murata Kazunori K
Clinical biochemistry 20191226
We describe the use of MALDI-TOF mass spectrometry in the analysis of a suspected case of gamma heavy chain disease. The patient had an abnormal serum immunofixation result where a monoclonal gamma heavy chain band was present without a corresponding light chain. Analysis by MALDI-TOF mass spectrometry revealed large peaks in the spectrum following IgG-specific purification. The m/z values of the peaks were outside the expected range for normal heavy chains or light chains. Corresponding peaks w ...[more]
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