Ontology highlight
ABSTRACT:
SUBMITTER: Mishra N
PROVIDER: S-EPMC7046651 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Mishra Nidhi N Agrahari Anand K AK Bose Priyanka P Singh Sumit K SK Singh Anoop S AS Tiwari Vinod K VK
Scientific reports 20200227 1
Among all the malaria parasites, P. falciparum is the most predominant species which has developed drug resistance against most of the commercial anti-malarial drugs. Thus, finding a new molecule for the inhibition of enzymes of P. falciparum is the pharmacological challenge in present era. Herein, ten novel molecules have been designed with an amalgamation of cinchonidine, carbohydrate moiety and triazole ring by utilizing copper-catalyzed click reaction of cinchonidine-derived azide and clicka ...[more]