Ontology highlight
ABSTRACT:
SUBMITTER: Huang YH
PROVIDER: S-EPMC7046678 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20200227 1
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) encode essential alcohol-metabolizing enzymes. While alcohol use is associated with spontaneously deep intracerebral haemorrhage (SDICH), particularly in males, the activities and genetic variants of ADH and ALDH may affect SDICH development. This case-control study was conducted to identify the interaction of alcohol use and SDICH with five single-nucleotide polymorphisms (SNPs): ADH1B rs1229984, ADH1C rs2241894, ALDH2 rs671, ALDH2 r ...[more]