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Biologically inspired ultrathin arrayed camera for high-contrast and high-resolution imaging.

ABSTRACT: Compound eyes found in insects provide intriguing sources of biological inspiration for miniaturised imaging systems. Here, we report an ultrathin arrayed camera inspired by insect eye structures for high-contrast and super-resolution imaging. The ultrathin camera features micro-optical elements (MOEs), i.e., inverted microlenses, multilayered pinhole arrays, and gap spacers on an image sensor. The MOE was fabricated by using repeated photolithography and thermal reflow. The fully packaged camera shows a total track length of 740??m and a field-of-view (FOV) of 73°. The experimental results demonstrate that the multilayered pinhole of the MOE allows high-contrast imaging by eliminating the optical crosstalk between microlenses. The integral image reconstructed from array images clearly increases the modulation transfer function (MTF) by ~1.57 times compared to that of a single channel image in the ultrathin camera. This ultrathin arrayed camera provides a novel and practical direction for diverse mobile, surveillance or medical applications.

SUBMITTER: Kim K

PROVIDER: S-EPMC7046746 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Biologically inspired ultrathin arrayed camera for high-contrast and high-resolution imaging.

Kim Kisoo K Jang Kyung-Won KW Ryu Jae-Kwan JK Jeong Ki-Hun KH

Light, science & applications 20200227

Compound eyes found in insects provide intriguing sources of biological inspiration for miniaturised imaging systems. Here, we report an ultrathin arrayed camera inspired by insect eye structures for high-contrast and super-resolution imaging. The ultrathin camera features micro-optical elements (MOEs), i.e., inverted microlenses, multilayered pinhole arrays, and gap spacers on an image sensor. The MOE was fabricated by using repeated photolithography and thermal reflow. The fully packaged camer ...[more]

PMID: 32140219

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Project description:PurposeTo assess cone density as a marker of early signs of retinopathy in patients with type II diabetes mellitus.MethodsAn adaptive optics (AO) retinal camera (rtx1™; Imagine Eyes, Orsay, France) was used to acquire images of parafoveal cones from patients with type II diabetes mellitus with or without retinopathy and from healthy controls with no known systemic or ocular disease. Cone mosaic was captured at 0° and 2°eccentricities along the horizontal and vertical meridians. The density of the parafoveal cones was calculated within 100×100-μm squares located at 500-μm from the foveal center along the orthogonal meridians. Manual corrections of the automated counting were then performed by 2 masked graders. Cone density measurements were evaluated with ANOVA that consisted of one between-subjects factor, stage of retinopathy and the within-subject factors. The ANOVA model included a complex covariance structure to account for correlations between the levels of the within-subject factors.ResultsTen healthy participants (20 eyes) and 25 patients (29 eyes) with type II diabetes mellitus were recruited in the study. The mean (± standard deviation [SD]) age of the healthy participants (Control group), patients with diabetes without retinopathy (No DR group), and patients with diabetic retinopathy (DR group) was 55 ± 8, 53 ± 8, and 52 ± 9 years, respectively. The cone density was significantly lower in the moderate nonproliferative diabetic retinopathy (NPDR) and severe NPDR/proliferative DR groups compared to the Control, No DR, and mild NPDR groups (P < 0.05). No correlation was found between cone density and the level of hemoglobin A1c (HbA1c) or the duration of diabetes.ConclusionsThe extent of photoreceptor loss on AO imaging may correlate positively with severity of DR in patients with type II diabetes mellitus. Photoreceptor loss may be more pronounced among patients with advanced stages of DR due to higher risk of macular edema and its sequelae.

Dataset Information

Biologically inspired ultrathin arrayed camera for high-contrast and high-resolution imaging.

Publications

Biologically inspired ultrathin arrayed camera for high-contrast and high-resolution imaging.

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