The association between NAT2 acetylator status and adverse drug reactions of sulfasalazine: a systematic review and meta-analysis.
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ABSTRACT:
SUBMITTER: Yee J
PROVIDER: S-EPMC7046788 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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The association between NAT2 acetylator status and adverse drug reactions of sulfasalazine: a systematic review and meta-analysis.
Yee Jeong J Kim So Min SM Han Ji Min JM Lee Nari N Yoon Ha Young HY Gwak Hye Sun HS
Scientific reports 20200227 1
N-acetyltransferase 2 (NAT2) acetylator status can be classified into three groups depending on the number of rapid alleles (e.g., NAT2*4): rapid, intermediate, and slow acetylators. Such acetylator status may influence the occurrence of adverse drug reactions (ADRs) during sulfasalazine treatment. This systematic review and meta-analysis aimed to evaluate the association between NAT2 acetylator status and ADRs of sulfasalazine. We searched for qualified studies in PubMed, Web of Science, Embase ...[more]
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