Ontology highlight
ABSTRACT:
SUBMITTER: Liang G
PROVIDER: S-EPMC7049122 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Liang Guang G Meng Wei W Huang Xiangjie X Zhu Wangyu W Yin Changtian C Wang Canwei C Fassan Matteo M Yu Yun Y Kudo Masahisa M Xiao Sisi S Zhao Chengguang C Zou Peng P Wang Yumin Y Li Xiaokun X Croce Carlo M CM Cui Ri R
Proceedings of the National Academy of Sciences of the United States of America 20200210 8
Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell lung cancer (NSCLC) accounts for over 80% of lung cancer cases. The RNA binding protein, QKI, belongs to the STAR family and plays tumor-suppressive functions in NSCLC. QKI-5 is a major isoform of QKIs and is predominantly expressed in NSCLC. However, the underlying mechanisms of QKI-5 in NSCLC progression remain unclear. We found that QKI-5 regulated microRNA (miRNA), miR-196b-5p, and its expression was signi ...[more]