MiR-196b-5p-mediated downregulation of FAS promotes NSCLC progression by activating IL6-STAT3 signaling.
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ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC7508872 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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miR-196b-5p-mediated downregulation of FAS promotes NSCLC progression by activating IL6-STAT3 signaling.
Huang Xiangjie X Xiao Sisi S Zhu Xinping X Yu Yun Y Cao Meng M Zhang Xiaodong X Li Shaotang S Zhu Wangyu W Wu Fengjiao F Zheng Xiaohui X Jin Libo L Xie Congying C Huang Xiaoying X Zou Peng P Li Xiaokun X Cui Ri R
Cell death & disease 20200922 9
Our recent study demonstrated that the QKI-5 regulated miRNA, miR-196b-5p, and it functions as an onco-microRNA in non-small cell lung cancer (NSCLC) by directly targeting GATA6 and TSPAN12. However, the role of miR-196b-5p in NSCLC progression and metastasis still remains unclear. We found that miR-196b-5p promotes lung cancer cell proliferation and colony formation by directly targeting tumor suppressor, FAS. The expression of FAS was significantly downregulated in NSCLC tissue samples and was ...[more]
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