Ontology highlight
ABSTRACT:
SUBMITTER: Trentini DB
PROVIDER: S-EPMC7049129 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Trentini Débora Broch DB Pecoraro Matteo M Tiwary Shivani S Cox Jürgen J Mann Matthias M Hipp Mark S MS Hartl F Ulrich FU
Proceedings of the National Academy of Sciences of the United States of America 20200211 8
Mammalian cells present a fingerprint of their proteome to the adaptive immune system through the display of endogenous peptides on MHC-I complexes. MHC-I-bound peptides originate from protein degradation by the proteasome, suggesting that stably folded, long-lived proteins could evade monitoring. Here, we investigate the role in antigen presentation of the ribosome-associated quality control (RQC) pathway for the degradation of nascent polypeptides that are encoded by defective messenger RNAs a ...[more]