Ontology highlight
ABSTRACT:
SUBMITTER: Saveanu L
PROVIDER: S-EPMC3342382 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Saveanu Loredana L van Endert Peter P
Frontiers in immunology 20120321
Production of MHC-I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding putative cross-presentation compartments have made it difficult to map the precise proteolytic events required for generation of cross-presented antigens. It is only in the past decade that the importance of aminoterminal trimming as the final step i ...[more]