Ontology highlight
ABSTRACT:
SUBMITTER: Yan L
PROVIDER: S-EPMC7049166 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Yan Liming L Qi Yuanbo Y Ricketson Derek D Li Lei L Subramanian Kelly K Zhao Jinghua J Yu Caiting C Wu Lijie L Sarsam Reta R Wong Melissa M Lou Zhiyong Z Rao Zihe Z Nunnari Jodi J Hu Junjie J
Proceedings of the National Academy of Sciences of the United States of America 20200210 8
The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood. Here, we determined the crystal structure of <i>Saccharomyces cerevisiae</i> short Mgm1 (s-Mgm1) in complex with GDP. It revealed an N-terminal GTPase (G) domain followed by two helix bundles (HB1 and HB2) and a unique C-terminal lipid-interacting stalk (LIS). Dimers can form through antiparallel HB interactions. Head-to-tail tri ...[more]