Unknown

Dataset Information

0

Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice.


ABSTRACT: ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus acidophilus. This study aims to investigate the effects of ProBiotic-4 on the microbiota-gut-brain axis and cognitive deficits, and to explore the underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. ProBiotic-4 was orally administered to 9-month-old SAMP8 mice for 12 weeks. We observed that ProBiotic-4 significantly improved the memory deficits, cerebral neuronal and synaptic injuries, glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice. ProBiotic-4 substantially attenuated aging-related disruption of the intestinal barrier and blood-brain barrier, decreased interleukin-6 and tumor necrosis factor-? at both mRNA and protein levels, reduced plasma and cerebral lipopolysaccharide (LPS) concentration, toll-like receptor 4 (TLR4) expression, and nuclear factor-?B (NF-?B) nuclear translocation in the brain. In addition, not only did ProBiotic-4 significantly decreased the levels of ?-H2AX, 8-hydroxydesoxyguanosine, and retinoic-acid-inducible gene-I (RIG-I), it also abrogated RIG-I multimerization in the brain. These findings suggest that targeting gut microbiota with probiotics may have a therapeutic potential for the deficits of the microbiota-gut-brain axis and cognitive function in aging, and that its mechanism is associated with inhibition of both TLR4-and RIG-I-mediated NF-?B signaling pathway and inflammatory responses.

SUBMITTER: Yang X 

PROVIDER: S-EPMC7049608 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice.

Yang Xueqin X   Yu Dongke D   Xue Li L   Li Hui H   Du Junrong J  

Acta pharmaceutica Sinica. B 20190707 3


ProBiotic-4 is a probiotic preparation composed of <i>Bifidobacterium lactis</i>, <i>Lactobacillus casei</i>, <i>Bifidobacterium bifidum</i>, and <i>Lactobacillus acidophilus</i>. This study aims to investigate the effects of ProBiotic-4 on the microbiota-gut-brain axis and cognitive deficits, and to explore the underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. ProBiotic-4 was orally administered to 9-month-old SAMP8 mice for 12 weeks. We observed that ProBi  ...[more]

Similar Datasets

| S-EPMC6232506 | biostudies-literature
| S-EPMC8571703 | biostudies-literature
| S-EPMC4209515 | biostudies-literature
| S-EPMC9198027 | biostudies-literature
| S-EPMC6304899 | biostudies-other
| S-EPMC7824888 | biostudies-literature
| S-EPMC10800857 | biostudies-literature
| S-EPMC9318165 | biostudies-literature
| S-EPMC8441017 | biostudies-literature
| S-EPMC9398688 | biostudies-literature