Regional, socioeconomic, and dietary factors influencing B-vitamins in human milk of urban Chinese lactating women at different lactation stages.

ABSTRACT: Background:Adequate B-vitamins concentrations in human milk are considered to be a prerequisite for healthy development of infants in early life. This study aims to determine the concentrations of B-vitamins in human milk from Chinese women and the relationships between their concentrations and different geographical origin, lactation stages, socioeconomic characteristics, and dietary intake. Methods:Human milk was obtained from 443 healthy lactating women from Beijing (n?=?150), Suzhou (n?=?146), and Guangzhou (n?=?147) cities. Thiamine, riboflavin, vitamin B3 (nicotinamide and nicotinic acid), and vitamin B6 (pyridoxal, pyridoxine, and pyridoxamine) in human milk were analyzed by high performance liquid chromatography-tandem mass spectrometry. Pantothenic acid, biotin, and folates in human milk were analyzed by microbiological assay. The information from one 24-h dietary recall and socioeconomic characteristics were collected by interview and structured questionnaire, respectively. Results:B-vitamins concentrations in human milk varied greatly among individuals. The median concentrations of B-vitamins of postpartum 5-11 d, 12-30 d, 31-60 d, 61-120 d, and 121-240 d were respectively as follows: thiamine 3.13, 5.07, 4.28, 5.65, 6.28 (?g/100 g); riboflavin 20.8, 20.2, 11.9, 13.6, 15.6 (?g/100 g); vitamin B3 194.0, 300.0, 261.0, 212.5, 218.0 (?g/100 g); pantothenic acid 236.5, 291.0, 254.0, 179.0, 189.0 (?g/100 g); vitamin B6 6.34, 7.58, 8.60, 9.34, 10.20 (?g/100 g); biotin 0.462, 0.834, 0.606, 0.523, 0.464 (?g/100 g); folates 0.730, 2.390, 2.440, 2.420, 2.330 (?g/100 g). The levels of B-vitamins presented regional differences and varied significantly among different lactation stages. The inversely associations of thiamine, vitamin B6, and folates with maternal BMI were found in multivariate analyses (p?

SUBMITTER: Xue Y 

PROVIDER: S-EPMC7050896 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature