Developing Broad-Spectrum Antivirals Using Porcine and Rhesus Macaque Models.
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ABSTRACT:
SUBMITTER: Qiu X
PROVIDER: S-EPMC7050986 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Developing Broad-Spectrum Antivirals Using Porcine and Rhesus Macaque Models.
Qiu Xueer X Taft Justin J Bogunovic Dusan D
The Journal of infectious diseases 20200301 6
ISG15-deficient humans exhibit permanent, low-level expression of antiviral effectors that safely protect them from various viruses. Because the murine ISG15 axis functions differently, we identified animal models that recapitulate the human condition for the development of ISG15-targeting broad-spectrum antivirals. Canine, porcine, and rhesus macaque ISG15, such as human ISG15, stabilize USP18, a potent inhibitor of type I interferon (IFN)-I. Type I Interferon-primed ISG15-knockout porcine and ...[more]
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