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Why does a mitochondrion need its individual cristae to be functionally autonomous?

ABSTRACT: We demonstrated that individual cristae in one mitochondrion function as autonomous electrochemical units, with this autonomy being maintained by cristae junction modulators. Here, I will summarize our novel findings, discuss the advantages of cristae insulation and reconcile this newly characterized cristae autonomy with previous studies showing coordinated cristae function.

SUBMITTER: Liesa M

PROVIDER: S-EPMC7051166 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Why does a mitochondrion need its individual cristae to be functionally autonomous?

Liesa Marc M

Molecular & cellular oncology 20200110 2

We demonstrated that individual cristae in one mitochondrion function as autonomous electrochemical units, with this autonomy being maintained by cristae junction modulators. Here, I will summarize our novel findings, discuss the advantages of cristae insulation and reconcile this newly characterized cristae autonomy with previous studies showing coordinated cristae function. ...[more]

PMID: 32158918

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