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Lactate dehydrogenase: a marker of diminished antitumor immunity.

ABSTRACT: Lactate dehydrogenase (LDH) levels are inversely related with response to checkpoint inhibitors. Elevated LDH levels are the product of enhanced glycolytic activity of the tumor and tumor necrosis due to hypoxia, the latter being associated with high tumor burden. In this review, we elucidate the effects of glycolysis and hypoxia on antitumor immunity and set forth ways to improve response to immunotherapy in cancer patients with elevated LDH levels. We discuss the current knowledge on combining immunotherapy with glycolysis inhibitors, anti-acidifying drugs, anti-angiogenic or cytoreductive therapy.

SUBMITTER: Van Wilpe S

PROVIDER: S-EPMC7051189 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Lactate dehydrogenase: a marker of diminished antitumor immunity.

Van Wilpe Sandra S Koornstra Rutger R Den Brok Martijn M De Groot Jan Willem JW Blank Christian C De Vries Jolanda J Gerritsen Winald W Mehra Niven N

Oncoimmunology 20200226 1

Lactate dehydrogenase (LDH) levels are inversely related with response to checkpoint inhibitors. Elevated LDH levels are the product of enhanced glycolytic activity of the tumor and tumor necrosis due to hypoxia, the latter being associated with high tumor burden. In this review, we elucidate the effects of glycolysis and hypoxia on antitumor immunity and set forth ways to improve response to immunotherapy in cancer patients with elevated LDH levels. We discuss the current knowledge on combining ...[more]

PMID: 32158624

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Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.

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Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity

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