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Local oral and nasal microbiome diversity in age-related macular degeneration.

ABSTRACT: Age-related macular degeneration (AMD) is a chronic degenerative disease of the retina. Recent reports have highlighted the potential role of mucosal surface microbes in the pathogenesis of AMD. In this case-control study, the composition of the nasal and oral microbiota in newly diagnosed neovascular age-related macular degeneration cases (6 male, 7 female) was compared to controls without retinal diseases (2 male, 3 female). PCR amplification of 16S rRNA genes was performed with universal primers amplifying the V4 variable region (515F-806R). Distinct microbial community characterization was achieved using Principal Coordinates Analysis (PCoA) of the Bray-Curtis index with comparative analysis between cases and controls performed within QIIME 2. Sequencing of all cases and controls revealed clear separation with strong beta diversity between oral and nasal microbial communities (p?

SUBMITTER: Rullo J

PROVIDER: S-EPMC7052252 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Local oral and nasal microbiome diversity in age-related macular degeneration.

Rullo Jacob J Far Parsa Mehraban PM Quinn Matthew M Sharma Neel N Bae Steven S Irrcher Isabella I Sharma Sanjay S

Scientific reports 20200302 1

Age-related macular degeneration (AMD) is a chronic degenerative disease of the retina. Recent reports have highlighted the potential role of mucosal surface microbes in the pathogenesis of AMD. In this case-control study, the composition of the nasal and oral microbiota in newly diagnosed neovascular age-related macular degeneration cases (6 male, 7 female) was compared to controls without retinal diseases (2 male, 3 female). PCR amplification of 16S rRNA genes was performed with universal prim ...[more]

PMID: 32123200

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