Genotypic divergence in mouse oocyte transcriptomes: possible pathways to hybrid vigor impacting fertility and embryogenesis.
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ABSTRACT:
SUBMITTER: Severance AL
PROVIDER: S-EPMC7052567 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Genotypic divergence in mouse oocyte transcriptomes: possible pathways to hybrid vigor impacting fertility and embryogenesis.
Severance Ashley L AL Midic Uros U Latham Keith E KE
Physiological genomics 20191223 2
What causes hybrid vigor phenotypes in mammalian oocytes and preimplantation embryos? Answering this question should provide new insight into determinants of oocyte and embryo quality and infertility. Hybrid vigor could arise through a variety of mechanisms, many of which must operate through posttranscriptional mechanisms affecting oocyte mRNA accumulation, stability, translation, and degradation. The differential regulation of such mRNAs may impact essential pathways and functions within the o ...[more]
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