Association of QT-Prolonging Medications With Risk of Autopsy-Defined Causes of Sudden Death.

ABSTRACT:

Importance

QT-prolonging medications (QTPMs) are a reported risk factor for sudden cardiac death (SCD) when defined by consensus criteria that presume an arrhythmic cause. The effect of QTPM on autopsy-defined sudden arrhythmic death (SAD) is unknown.

Objective

To evaluate the association between QTPM and autopsy-defined SAD vs nonarrhythmic cause of sudden death.

Design, setting, and participants

This prospective countywide case-control study included World Health Organization-defined (presumed) SCD cases who underwent autopsy as part of the San Francisco Postmortem Systematic Investigation of Sudden Cardiac Death Study (POST SCD) to determine arrhythmic or nonarrhythmic cause, and control deaths due to trauma (hereinafter referred to as trauma controls) in San Franc

SUBMITTER: Simpson TF 

PROVIDER: S-EPMC7052791 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature