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Long QT molecular autopsy in sudden infant death syndrome.

ABSTRACT: To describe experience of long QT (LQT) molecular autopsy in sudden infant death syndrome (SIDS).Descriptive audit from two distinct periods: (1) A prospective, population-based series between 2006 and 2008 ('unselected'). (2) Before and after 2006-2008, with testing guided by a cardiac genetic service ('selected'). LQT genes 1, 2, 3, 5, 6 and 7 were sequenced. Next of kin were offered cardiac evaluation.New Zealand.102 SIDS cases.Nil. Main outcome measures Detection of genetic variants.Maori 49 (47%), and Pacific island 24 (23%), infants were over-represented. Risk factors were common; bed sharing was reported in 49%. Rare genetic variants were commoner within the selected than unselected populations (5 of 31 infants (16%) vs 3 of 71 infants (4%) p?

SUBMITTER: Glengarry JM 

PROVIDER: S-EPMC4078670 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Long QT molecular autopsy in sudden infant death syndrome.

Glengarry Joanna Moira JM   Crawford Jackie J   Morrow Paul Lowell PL   Stables Simon Robert SR   Love Donald Roy DR   Skinner Jonathan Robert JR  

Archives of disease in childhood 20140304 7

<h4>Objective</h4>To describe experience of long QT (LQT) molecular autopsy in sudden infant death syndrome (SIDS).<h4>Design</h4>Descriptive audit from two distinct periods: (1) A prospective, population-based series between 2006 and 2008 ('unselected'). (2) Before and after 2006-2008, with testing guided by a cardiac genetic service ('selected'). LQT genes 1, 2, 3, 5, 6 and 7 were sequenced. Next of kin were offered cardiac evaluation.<h4>Setting</h4>New Zealand.<h4>Patients</h4>102 SIDS cases  ...[more]

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