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LncRNAs regulate metabolism in cancer.

ABSTRACT: Metabolic reprogramming is a hallmark of cancer. Mammalian genome is characterized by pervasive transcription, generating abundant non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are freshly discovered functional ncRNAs exerting extensive regulatory impact through diverse mechanisms. Emerging studies have revealed widespread roles of lncRNAs in the regulation of various cellular activities, including metabolic pathways. In this review, we summarize the latest advances regarding the regulatory roles of lncRNAs in cancer metabolism, particularly their roles in mitochondrial function, glucose, glutamine, and lipid metabolism. Moreover, we discuss the clinical application and challenges of targeting lncRNAs in cancer metabolism. Understanding the complex and special behavior of lncRNAs will allow a better depiction of cancer metabolic networks and permit the development of lncRNA-based clinical therapies by targeting cancer metabolism.

SUBMITTER: Lin W

PROVIDER: S-EPMC7053319 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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LncRNAs regulate metabolism in cancer.

Lin Wenyu W Zhou Qiyin Q Wang Chao-Qun CQ Zhu Liyuan L Bi Chao C Zhang Shuzhen S Wang Xian X Jin Hongchuan H

International journal of biological sciences 20200210 7

Metabolic reprogramming is a hallmark of cancer. Mammalian genome is characterized by pervasive transcription, generating abundant non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are freshly discovered functional ncRNAs exerting extensive regulatory impact through diverse mechanisms. Emerging studies have revealed widespread roles of lncRNAs in the regulation of various cellular activities, including metabolic pathways. In this review, we summarize the latest advances regarding the regu ...[more]

PMID: 32174794

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LncRNAs regulate metabolism in cancer.

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LncRNAs regulate metabolism in cancer.

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