Fibroblast growth factor 10 alleviates particulate matter-induced lung injury by inhibiting the HMGB1-TLR4 pathway.
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ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC7053597 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Fibroblast growth factor 10 alleviates particulate matter-induced lung injury by inhibiting the HMGB1-TLR4 pathway.
Liu Lingjing L Song Chenjian C Li Jingli J Wang Qiang Q Zhu Mingyang M Hu Yiran Y Chen Junjie J Chen Chaolei C Zhang Jin-San JS Dong Nian N Chen Chengshui C
Aging 20200120 2
Exposure to particulate matter (PM) is associated with increased incidence of respiratory diseases. The present study aimed to investigate the roles of fibroblast growth factor 10 (FGF10) in PM-induced lung injury. Mice were intratracheally instilled with FGF10 or phosphate-buffered saline at one hour before instillation of PM for two consecutive days. In addition, the anti-inflammatory impact of FGF10 <i>in vitro</i> and its effect on the high-mobility group box 1 (HMGB1)-toll-like receptor 4 ( ...[more]
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