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Immunological analyses reveal an immune subtype of uveal melanoma with a poor prognosis.


ABSTRACT: Uveal melanoma is an aggressive intraocular malignancy that often exhibits low immunogenicity. Metastatic uveal melanoma samples frequently exhibit monosomy 3 or BAP1 deficiency. In this study, we used bioinformatic methods to investigate the immune infiltration of uveal melanoma samples in public datasets. We first performed Gene Set Enrichment/Variation Analyses to detect immunological pathways that are altered in tumors with monosomy 3 or BAP1 deficiency. We then conducted an unsupervised clustering analysis to identify distinct immunologic molecular subtypes of uveal melanoma. We used CIBERSORT and ESTIMATE with RNA-seq data from The Cancer Genome Atlas and the GSE22138 microarray dataset to determine the sample-level immune subpopulations and immune scores of uveal melanoma samples. The Kaplan-Meier method and log-rank test were used to assess the prognostic value of particular immune cells and genes in uveal melanoma samples. Through these approaches, we discovered uveal melanoma-specific immunologic features, which may provide new insights into the tumor microenvironment and enhance the development of immunotherapies in the future.

SUBMITTER: Pan H 

PROVIDER: S-EPMC7053626 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Immunological analyses reveal an immune subtype of uveal melanoma with a poor prognosis.

Pan Hui H   Lu Linna L   Cui Junqi J   Yang Yuan Y   Wang Zhaoyang Z   Fan Xianqun X  

Aging 20200118 2


Uveal melanoma is an aggressive intraocular malignancy that often exhibits low immunogenicity. Metastatic uveal melanoma samples frequently exhibit monosomy 3 or <i>BAP1</i> deficiency. In this study, we used bioinformatic methods to investigate the immune infiltration of uveal melanoma samples in public datasets. We first performed Gene Set Enrichment/Variation Analyses to detect immunological pathways that are altered in tumors with monosomy 3 or <i>BAP1</i> deficiency. We then conducted an un  ...[more]

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