Ontology highlight
ABSTRACT:
SUBMITTER: Pan H
PROVIDER: S-EPMC7053626 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Pan Hui H Lu Linna L Cui Junqi J Yang Yuan Y Wang Zhaoyang Z Fan Xianqun X
Aging 20200118 2
Uveal melanoma is an aggressive intraocular malignancy that often exhibits low immunogenicity. Metastatic uveal melanoma samples frequently exhibit monosomy 3 or <i>BAP1</i> deficiency. In this study, we used bioinformatic methods to investigate the immune infiltration of uveal melanoma samples in public datasets. We first performed Gene Set Enrichment/Variation Analyses to detect immunological pathways that are altered in tumors with monosomy 3 or <i>BAP1</i> deficiency. We then conducted an un ...[more]