Ontology highlight
ABSTRACT:
SUBMITTER: Alexandrov LB
PROVIDER: S-EPMC7054213 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Alexandrov Ludmil B LB Kim Jaegil J Haradhvala Nicholas J NJ Huang Mi Ni MN Tian Ng Alvin Wei AW Wu Yang Y Boot Arnoud A Covington Kyle R KR Gordenin Dmitry A DA Bergstrom Erik N EN Islam S M Ashiqul SMA Lopez-Bigas Nuria N Klimczak Leszek J LJ McPherson John R JR Morganella Sandro S Sabarinathan Radhakrishnan R Wheeler David A DA Mustonen Ville V Getz Gad G Rozen Steven G SG Stratton Michael R MR
Nature 20200205 7793
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature<sup>1</sup>. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium<sup>2</sup> of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we characterized mutational signatures using 84,729,690 somatic mutations from 4,645 whole-genome and 19,184 exome sequences that encompass most types of cancer. We i ...[more]