Dataset Information

Cigarette smoking is associated with higher thyroid hormone and lower TSH levels: the PREVEND study.

ABSTRACT:

Purpose

The extent to which smoking is associated with thyroid stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) when taking account of clinical variables including alcohol consumption is unclear. We aimed to determine associations of TSH, FT4, and FT3 levels with current smoking.

Methods

A cross-sectional study was performed in 5766 euthyroid participants (Prevention of Renal and Vascular End-Stage Disease cohort). Current smoking was determined by self-report, categorized as never, former, and current (?20 and >20 cigarettes per day). Smoke exposure was determined by urinary cotinine.

Results

Current smoking of ?20 and >20 cigarettes per day was associated with lower TSH and higher FT3 levels. FT4 levels were higher in subjects smoking <20 cigarettes per day vs. never and former smokers. Current smokers also consumed more alcohol. Multivariable linear regression analyses adjusted for age, sex, anti-TPO autoantibody positivity, alcohol consumption, and other variables demonstrated that lower TSH, higher FT4 and higher FT3 were associated with smoking ?20 cigarettes per day vs. subjects who never smoked (P?20 cigarettes per day. In agreement, TSH was inversely, whereas FT4 and FT3 levels were positively associated with urinary cotinine (P?30?g per day conferred higher TSH and lower FT3 levels.

Conclusions

Cigarette smoking is associated with modestly higher FT4 and FT3, and lower TSH levels, partly opposing effects of alcohol consumption.

SUBMITTER: Gruppen EG

PROVIDER: S-EPMC7054375 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Publications

Cigarette smoking is associated with higher thyroid hormone and lower TSH levels: the PREVEND study.

Gruppen Eke G EG Kootstra-Ros Jenny J Kobold Anneke Muller AM Connelly Margery A MA Touw Daan D Bos Jens H J JHJ Hak Eelko E Links Thera P TP Bakker Stephan J L SJL Dullaart Robin P F RPF

Endocrine 20191109 3

<h4>Purpose</h4>The extent to which smoking is associated with thyroid stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) when taking account of clinical variables including alcohol consumption is unclear. We aimed to determine associations of TSH, FT4, and FT3 levels with current smoking.<h4>Methods</h4>A cross-sectional study was performed in 5766 euthyroid participants (Prevention of Renal and Vascular End-Stage Disease cohort). Current smoking was determined by ...[more]

PMID: 31707605

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Project description:Thyroid stimulating hormone (TSH) hormone levels are normally tightly regulated within an individual; thus, relatively small variations may indicate thyroid disease. Genome-wide association studies (GWAS) have identified variants in PDE8B and FOXE1 that are associated with TSH levels. However, prior studies lacked racial/ethnic diversity, limiting the generalization of these findings to individuals of non-European ethnicities. The Electronic Medical Records and Genomics (eMERGE) Network is a collaboration across institutions with biobanks linked to electronic medical records (EMRs). The eMERGE Network uses EMR-derived phenotypes to perform GWAS in diverse populations for a variety of phenotypes. In this report, we identified serum TSH levels from 4,501 European American and 351 African American euthyroid individuals in the eMERGE Network with existing GWAS data. Tests of association were performed using linear regression and adjusted for age, sex, body mass index (BMI), and principal components, assuming an additive genetic model. Our results replicate the known association of PDE8B with serum TSH levels in European Americans (rs2046045 p = 1.85×10-17, β = 0.09). FOXE1 variants, associated with hypothyroidism, were not genome-wide significant (rs10759944: p = 1.08×10-6, β = -0.05). No SNPs reached genome-wide significance in African Americans. However, multiple known associations with TSH levels in European ancestry were nominally significant in African Americans, including PDE8B (rs2046045 p = 0.03, β = -0.09), VEGFA (rs11755845 p = 0.01, β = -0.13), and NFIA (rs334699 p = 1.50×10-3, β = -0.17). We found little evidence that SNPs previously associated with other thyroid-related disorders were associated with serum TSH levels in this study. These results support the previously reported association between PDE8B and serum TSH levels in European Americans and emphasize the need for additional genetic studies in more diverse populations.

Dataset Information

Cigarette smoking is associated with higher thyroid hormone and lower TSH levels: the PREVEND study.

Purpose

Methods

Results

Conclusions

Publications

Cigarette smoking is associated with higher thyroid hormone and lower TSH levels: the PREVEND study.

Similar Datasets

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