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The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans.


ABSTRACT: Caenorhabditis elegans mechanoreceptors located in ASG sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of xanthine dehydrogenase (XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the mechanoreceptor-expressing ASG. Ca2+ imaging revealed that ASG neurons respond to warm temperature via the mechanoreceptor DEG-1, a degenerin/epithelial Na+ channel (DEG/ENaC), which in turn affects downstream AIN and AVJ circuits. Ectopic expression of DEG-1 in the ASE gustatory neuron results in the acquisition of warm sensitivity, while electrophysiological analysis revealed that DEG-1 and human MDEG1 were involved in warm sensation. Taken together, these results suggest that cold tolerance is regulated by mechanoreceptor-mediated circuit calculation.

SUBMITTER: Takagaki N 

PROVIDER: S-EPMC7054665 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans.

Takagaki Natsune N   Ohta Akane A   Ohnishi Kohei K   Kawanabe Akira A   Minakuchi Yohei Y   Toyoda Atsushi A   Fujiwara Yuichiro Y   Kuhara Atsushi A  

EMBO reports 20200203 3


Caenorhabditis elegans mechanoreceptors located in ASG sensory neurons have been found to sense ambient temperature, which is a key trait for animal survival. Here, we show that experimental loss of xanthine dehydrogenase (XDH-1) function in AIN and AVJ interneurons results in reduced cold tolerance and atypical neuronal response to changes in temperature. These interneurons connect with upstream neurons such as the mechanoreceptor-expressing ASG. Ca<sup>2+</sup> imaging revealed that ASG neuron  ...[more]

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