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A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.

ABSTRACT: Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought.

SUBMITTER: Marsh EK

PROVIDER: S-EPMC3047536 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.

Marsh Elizabeth K EK van den Berg Maaike C W MC May Robin C RC

PloS one 20110302 3

Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is ...[more]

PMID: 21399680

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