Ontology highlight
ABSTRACT:
SUBMITTER: Figueiredo JL
PROVIDER: S-EPMC7055260 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Figueiredo Jose-Luiz JL Santa-Cruz Fernando F Lima-Filho José Luiz JL Hilgendorf Ingo I Aikawa Masanori M Pittet Mikael J MJ Nahrendorf Matthias M Weissleder Ralph R Swirski Filip K FK Robbins Clinton S CS
Scientific reports 20200304 1
The spleen is a large lymphoid organ located in the abdomen that filters blood and regulates the immune system. The extent of mobilization of splenic immune cells to peripheral tissues in health and disease, however, remains poorly understood. This is due, in large part, to a lack of in vivo, spleen-specific lineage tagging strategies. Here, we describe a detailed practical protocol of spleen transplantation and its evaluation for long-term graft survival. Unlike implantation of splenic morsels ...[more]