Ontology highlight
ABSTRACT:
SUBMITTER: Asenjo HG
PROVIDER: S-EPMC7056320 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Asenjo Helena G HG Gallardo Amador A López-Onieva Lourdes L Tejada Irene I Martorell-Marugán Jordi J Carmona-Sáez Pedro P Landeira David D
Science advances 20200304 10
When self-renewing pluripotent cells receive a differentiation signal, ongoing cell duplication needs to be coordinated with entry into a differentiation program. Accordingly, transcriptional activation of lineage specifier genes and cell differentiation is confined to the G<sub>1</sub> phase of the cell cycle by unknown mechanisms. We found that Polycomb repressive complex 2 (PRC2) subunits are differentially recruited to lineage specifier gene promoters across cell cycle in mouse embryonic ste ...[more]