Ontology highlight
ABSTRACT:
SUBMITTER: Yao Z
PROVIDER: S-EPMC7056549 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Yao Zhangting Z Murali Bhavna B Ren Qihao Q Luo Xianmin X Faget Douglas V DV Cole Tom T Ricci Biancamaria B Thotala Dinesh D Monahan Joseph J van Deursen Jan M JM Baker Darren D Faccio Roberta R Schwarz Julie K JK Stewart Sheila A SA
Cancer research 20200113 5
Chemotherapy is important for cancer treatment, however, toxicities limit its use. While great strides have been made to ameliorate the acute toxicities induced by chemotherapy, long-term comorbidities including bone loss remain a significant problem. Chemotherapy-driven estrogen loss is postulated to drive bone loss, but significant data suggests the existence of an estrogen-independent mechanism of bone loss. Using clinically relevant mouse models, we showed that senescence and its senescence- ...[more]