Ontology highlight
ABSTRACT:
SUBMITTER: Kim HN
PROVIDER: S-EPMC7566701 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Kim Ha-Neui HN Xiong Jinhu J MacLeod Ryan S RS Iyer Srividhya S Fujiwara Yuko Y Cawley Keisha M KM Han Li L He Yonghan Y Thostenson Jeff D JD Ferreira Elisabeth E Jilka Robert L RL Zhou Daohong D Almeida Maria M O'Brien Charles A CA
JCI insight 20201002 19
In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encoded by Tnfsf11. Tnfsf11 mRNA increases in cortical bone of aged mice, suggesting a mechanism underlying the bone loss. To address this possibility, we aged mice lacking RANKL in osteocytes. Whereas control mice lost cortical bone between 8 and 24 mont ...[more]