Ontology highlight
ABSTRACT:
SUBMITTER: Shu Y
PROVIDER: S-EPMC7056567 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Shu Yi Y Wang Yi Y Lv Wen-Qiong WQ Peng Dan-Yi DY Li Juan J Zhang Hang H Jiang Guang-Jie GJ Yang Bi-Jie BJ Liu Shan S Zhang Jia J Chen Yan-Hua YH Tang Shi S Wan Ke-Xing KX Yuan Jun-Tao JT Guo Wei W Fu Guo G Qi Xin-Kun XK Liu Zhi-Dai ZD Liu Hai-Yan HY Yang Chao C Zhang Ling-Huan LH Liu Fang-Jie FJ Yu Jie J Zhang Peng-Hui PH Qu Bin B Zhao Hui H He Tong-Chuan TC Zou Lin L
Cancer research 20191210 5
T-cell acute lymphoblastic leukemia (T-ALL) is a type of aggressive leukemia with inferior prognosis. Although activating mutations of <i>NOTCH1</i> are observed in most T-ALL cases, these mutations alone are not sufficient to drive the full development of T-ALL. β-Arrestins (ARRB) are versatile and multifunctional adapter proteins that regulate diverse cellular functions, including promoting the development of cancer. However, the role of ARRBs in T-ALL has largely remained elusive. In this stu ...[more]