Ontology highlight
ABSTRACT:
SUBMITTER: Zhovtis Ryerson L
PROVIDER: S-EPMC7057061 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Zhovtis Ryerson Lana L Li Xiaochun X Goldberg Judith D JD Hoyt Tamara T Christensen Angel A Metzger Ryan R RR Kister Ilya I Foley John J
Neurology(R) neuroimmunology & neuroinflammation 20200204 2
<h4>Objective</h4>To determine if the concentration and saturation of natalizumab (NTZ) administration at extended interval dosing (EID; every 5-8 weeks) over 18 months is able to be maintained in the range considered adequate to sustain the clinical efficacy of NTZ.<h4>Methods</h4>In a cross-sectional assessment of patients with multiple sclerosis (MS) who received standard interval dosing (every 4 weeks) or EID, serum NTZ concentrations were measured using ELISA, and α<sub>4</sub>-integrin rec ...[more]