Ontology highlight
ABSTRACT:
SUBMITTER: Brown ME
PROVIDER: S-EPMC7058304 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Brown Michael E ME Bedinger Daniel D Lilov Asparouh A Rathanaswami Palaniswami P Vásquez Maximiliano M Durand Stéphanie S Wallace-Moyer Ian I Zhong Lihui L Nett Juergen H JH Burnina Irina I Caffry Isabelle I Lynaugh Heather H Sinclair Melanie M Sun Tingwan T Bukowski John J Xu Yingda Y Abdiche Yasmina Noubia YN
PloS one 20200305 3
Here we describe an industry-wide collaboration aimed at assessing the binding properties of a comprehensive panel of monoclonal antibodies (mAbs) against programmed cell death protein 1 (PD-1), an important checkpoint protein in cancer immunotherapy and validated therapeutic target, with well over thirty unique mAbs either in clinical development or market-approved in the United States, the European Union or China. The binding kinetics of the PD-1/mAb interactions were measured by surface plasm ...[more]