Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC7058826 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Li Chen C Stoma Svetlana S Lotta Luca A LA Warner Sophie S Albrecht Eva E Allione Alessandra A Arp Pascal P PP Broer Linda L Buxton Jessica L JL Da Silva Couto Alves Alexessander A Deelen Joris J Fedko Iryna O IO Gordon Scott D SD Jiang Tao T Karlsson Robert R Kerrison Nicola N Loe Taylor K TK Mangino Massimo M Milaneschi Yuri Y Miraglio Benjamin B Pervjakova Natalia N Russo Alessia A Surakka Ida I van der Spek Ashley A Verhoeven Josine E JE Amin Najaf N Beekman Marian M Blakemore Alexandra I AI Canzian Federico F Hamby Stephen E SE Hottenga Jouke-Jan JJ Jones Peter D PD Jousilahti Pekka P Mägi Reedik R Medland Sarah E SE Montgomery Grant W GW Nyholt Dale R DR Perola Markus M Pietiläinen Kirsi H KH Salomaa Veikko V Sillanpää Elina E Suchiman H Eka HE van Heemst Diana D Willemsen Gonneke G Agudo Antonio A Boeing Heiner H Boomsma Dorret I DI Chirlaque Maria-Dolores MD Fagherazzi Guy G Ferrari Pietro P Franks Paul P Gieger Christian C Eriksson Johan Gunnar JG Gunter Marc M Hägg Sara S Hovatta Iiris I Imaz Liher L Kaprio Jaakko J Kaaks Rudolf R Key Timothy T Krogh Vittorio V Martin Nicholas G NG Melander Olle O Metspalu Andres A Moreno Concha C Onland-Moret N Charlotte NC Nilsson Peter P Ong Ken K KK Overvad Kim K Palli Domenico D Panico Salvatore S Pedersen Nancy L NL Penninx Brenda W J H BWJH Quirós J Ramón JR Jarvelin Marjo Riitta MR Rodríguez-Barranco Miguel M Scott Robert A RA Severi Gianluca G Slagboom P Eline PE Spector Tim D TD Tjonneland Anne A Trichopoulou Antonia A Tumino Rosario R Uitterlinden André G AG van der Schouw Yvonne T YT van Duijn Cornelia M CM Weiderpass Elisabete E Denchi Eros Lazzerini EL Matullo Giuseppe G Butterworth Adam S AS Danesh John J Samani Nilesh J NJ Wareham Nicholas J NJ Nelson Christopher P CP Langenberg Claudia C Codd Veryan V
American journal of human genetics 20200227 3
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant ...[more]